In honor of Dysautonomia Awareness Month and POTS Awareness Day, we hosted a conversation about living with Orthostatic Intolerance.

Drs. Kaufman & Dempsey discussed how they use GLP-1/GIP meds off label in their respective practices and how clinical results have varied with single vs dual agents at micro, ultra low, and normal doses.

A personalized treatment approach is critical based on identified needs, medical access, stage of life, and available resources. Collective knowledge and scientific research is also important.

Biochemical Pathways and Clinical Applications in ME/CFS & LC. BornFree Protocol Steps and Typical Timing.

Inflammation triggers a vicious cycle affecting blood flow and tissue oxygenation. RAGE pathway's role in inflammation and microclot formation is significant. Discussion on innovative treatments and challenges in healthcare access.

Clinical discussion with research data shown on Improving ME/CFS, POTS, migraines, fibromyalgia, long COVID, ADHD, IC, IBS, and more by treating compressed, congested, and obstructed veins in pelvis using interventional radiology.

Hundreds of patients around the world collected lactate measurements using at-home finger prick devices and then submitted their results for analysis.

Overlap with MCAS and Long Covid with tick-borne infections. Discussion of mast cell biology, triggers and symptoms of MCAS, neuroinflammation, testing, treatment.

The 6 stages of the Remission Biome protocol for ME/CFS/Long Covid are explained in detail.

In part 2 of 2, Johns Hopkins ME/CFS and Lovg Covid clinicians / researchers Peter Rowe and Alba Azola come back for more Q&A.

In part 1 of 2, Dr. Azola's gives her "Practical Clinical Approach to the ME/CFS Patient" presentation, with fellow Johns Hopkins ME/CFS and Lovg Covid clinician / researcher Peter Rowe adding wisdom, experience, and clarity. Some Q&A.

Dr. Naviaux discusses how CCI and ATP signaling are connected, pathogenesis and salugenisis: disease production and recovery, and potential treatments for ME/CFS.

The Remission Biome data analysis team share preliminary results for the Remission Biome project with a focus on Transient Remission Events (TRE), across the pilot, 1.5 group and the Renegade 50.

Dr. Yellman discusses ME/CFS Comorbidities including hEDS, MCAS, CCI, SFPN, CCI/AAI, Tethered Cord, Venous Congestion, MTS, Nutcracker, and IIH.

Multi-Modal MRI Reveals Brainstem Abnormalities in ME/CFS, ME/CFS hypothesis with brainstem connections, Lightning talks, and more.

An update on the state of our now Non-profit 501c3 organization Renegade Research, as well as a status update for our largest project, Remission Biome (RB). In RB, a transient remission event (TRE) is not needed to get a baseline increase. Now there is a choice on antibiotics or not for intervention stage 4.

In this first installment, Jeff Wood, Michael VanElzakker, PhD, and Brayden Yellman, MD, discuss the mechanical basis model, the brainstem, and neuroanatomical considerations for MECFS.

Dr. Ryan, an Australian gastroenterologist and hepatologist, discusses disorders of the gut-brain axis in ME/CFS and Long Covid and her successful approach with her patients.

In Part 3, Dr. Afrin walks us through MCAS treatment options and their rationale and other key issues that arise when treating MCAS patients.

In part 2, Dr. Afrin discusses diagnosing MCAS and it's multiple presentations for 1.5 hrs, then answers questions from an audience of clinicians, researchers, and patients for 2 hrs.

Mast Cell Activation Syndrome with Dr. Afrin - Part 1 is an Overview and History and includes some case studies, triggers of mast cells, gene mutations, tests, and prevalence.

Renegade Research Roundtable with Liisa Selin, Anna Gil, Roshan Kumar, Rivka Solomon, Megan Fitzgerald on ME/CFS/LC CD8 T Cell Dysfunction Research, Immune Repertoire Profiling, and Patient Rep Insights.

John Haughton, MD walks us through some mechanisms & potential pathophysiology of #longcovid & #mecfs, as well as potential economic and accessible treatments that are being used to target symptoms. Dr. Haughton shares his personal experience with Long covid.

Dr. Davenport discusses evidence for bioenergetic impairments from systems to molecules, testing for bioenergetic impairments: current practices and future directions, and bioenergetic impairments as a treatable condition.

Ilene Ruhoy, MD, PhD, and David Kaufman, MD, return to Renegade Research Clinician's Roundtable to answer more questions about Infection Associated Chronic Illnesses.

Diagnosing and Treating Cranial Cervical Instability (CCI), Atlantoaxial Instability (AAI), and Occult Tethered Cord (OTC) in ME, LC, & Hypermobility Syndrome. Includes information on imaging and surgical and non-surgical options.

Single-cell Immune Profiling Before, During, and After Antibiotics-induced (Transient) Complete Remission of ME/CFS

Medical discussion of ME/CFS and other Infection Associated Chronic Illness (IACI)

Dr. Rowe presents on biomechanical issues including thoracic outlet syndrome (TOS), neuroanatomic problems including cervical stenosis & cranial cervical instability (CCI), and Mast Cell Activation.

Besides OI, brain blow flow, and venous compression syndromes, Dr. Rowe talks about ME/CFS, EDS and HSD, pelvic congestion syndrome (PCS), May-Thurner Syndrome, Cerebral Blood Flow (CBF) ; CBF & Long Covid (LC), Nutcracker Syndrome, Superior Mesenteric Artery Syndrome, Median Arcuate Ligament syndrome, Provoked Post Exertional Malaise (PEM), Orthostatic Hypotension (OH), Delayed OH, NMH, & POTS.