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Innovation Inn - Quantifying Post-Exertional Malaise (PEM)

A close up of a fancy double doorway into a tall brick building. A banner hangs over saying "Innovation Inn." Just about the door is are the word and image logos for Renegade Research. The doors have glass windows with metal scrollwork. There is window is above the door. Warm yellow light comes through the doors and window. Metal strips bent into spherical chandelier is visible through the window.

Five patient-researcher members of the Renegade Research team will gather in Montreal, Canada, August 3-9, to do self-measurements related to Post Exertional Malaise (PEM) / Post Exertional Neuroimmune Exhaustion (PENE). The project, called Innovation Inn, was funded by Vitalik Buterin’s Kanro organization ($8k) and $10,000+ from private donors. There will also be a small symposium with researchers and clinicians.


Before, during, and after PEM, the participants will measure the following :


  • RNA Sequencing (Amatica) + biobanking

  • Heart rate variability including detailed autonomic measurements (Polar H10 monitors and custom rings)

  • Blood flow to the head (Lumia)

  • Electroencephalography (Muse)

  • Muscle oxygen (Moxy)

  • Continuous Glucose Monitor (CGM)

  • Metabolism (Lumen)

  • Lactate (Nova)

  • Remote cognitive testing (Braincheck)

  • Capillaroscopy

  • Pupillometry

  • Cytokines

  • Daily symptom and function tracking (Bearable & PEM related questionnaires)


With additional funding we would like to add these measures (prices include 2 samples for each of the 5 participants):


  • Urinary organic acids (Mosaic) - $3000

  • Metabolomics (Iollo) - $4500

  • Single-cell immune profiling (ImYoo) - $5500

  • Mitochondrial testing (ME Screen) - $6000


If you would like to support this work, please donate to fund additional testing​.


Reach out to Outreach@Renegade-Research.org with questions or if would like your donation to be dedicated to a specific type of testing.


Follow @tessfalor and @RenegadeRes on X for Innovation Inn news.




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